Adrenal Cortical The adrenal cortex is the outer region and also the largest part of an adrenal gland. It is divided into three separate zones: zona glomerulosa, zona fasciculata and zona reticularis. Each zone is responsible for producing specific hormones.

The Adrenal Medulla and Cortex Produce Very Different Hormones. We have two adrenal glands located on the top of both kidneys. They are triangular-shaped and about the size and color of a fortune cookie. Each gland consists of a medulla (the center of the gland) which is surrounded by the cortex.

Function of the Adrenal Medulla.

The adrenal medulla is responsible for producing catecholamines, or adrenaline type hormones such as epinephrine and norepinephrine. We have all experienced that sudden panic feeling and anxiety when something happens suddenly and unexpectedly and we get scared. All of a sudden we have tingles and we feel like we need to run away or stand up and fight. This is the “fight-or-flight” symptoms and it is caused by the sudden release of adrenaline from our adrenal glands. (yes, adrenaline is called this because it comes from the adrenal gland). Adrenaline as we call it generically can be broken down into two different hormones that the adrenal medulla produces: epinephrine and norepinepherine.

Function of the Adrenal Cortex.

The adrenal cortex produces a handful of hormones necessary for fluid and electrolyte (salt) balance in the body such as cortisol and aldosterone. The adrenal cortex also makes small amounts of sex hormones but this only becomes important if overproduction is present (most sex hormones are produced by the testes and ovaries). The three layers of the adrenal cortex are:

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