Prescription Gel Eye Drops for Dry Eyes

Help patients see eye care differently with Eye Drop Gel or Patch

Do you suffer from Dry Eyes? Stinging, Burning, sandy, gritty, excessive watering, red eye with fluctuating vision and difficulty wearing contacts? Over 30 million people suffer with Chronic Dry Eye. Dry eye is a condition where our eyes do not produce healthy tears. When you blink, a healthy tear film comprised of an oily, watery, and mucous layer should coat your eyes and prevent dryness. When one of these three layers are malfunctioning, our eyes become dry.

HOW DOES IT WORK?

Top Products are made with hydrating polymers that form a protective matrix over your eyes, moisturizing hyaluronic acid, and revitalizing trehalose.

POVIDONE (active ingredient)

A hydrating polymer that significantly decreases dry eye discomfort. Hydrating polymers form a protective matrix over the eye.

HYALURONIC ACID “HA” (enhancer)

Also called sodium hyaluronate is widely used and well known in skin care and eye care. One of the most water-loving molecules in nature, it can be described as “nature’s moisturizer”. It can bind 1000 times its weight in water.

TREHALOSE (enhancer)

Trehalose is a bioprotectant that can be found in nature. It is a disaccharide synthetized by plants such as the Rose of Jericho, as a response to stress (dryness, osmopressure, freezing). Trehalose is extracted from starch in a large-scale enzymatic process.

The Rose of Jericho (Selaginella lepidophylla), or resurrection plant, can survive extreme dehydration thanks to trehalose.

Chronic Dry Eye Products & Options

Dry Eye Plugs

MiboFLO Treatment

MiboFLO Certified Dry Eye Center and provide a FDA approved treatment that offers relief for dry eyes. The device supplies continuous controlled heat that is applied to the outer eyelid, along with a specialized gel. The heat is absorbed deep into the tissue and breaks down the hardened lipids in the meibomian glands. This results in having your own glands secrete the necessary oils you need and also removes build up debris. Patients usually see immediate results after their first treatment but a set of three treatments offers the longest-lasting benefit.

Eyelid Hygiene Products

Ocular coherence tomography

An OCT is a non-invasive imaging tool. The OCT uses light to take a cross section image of your retina. We are capable of seeing the layers of the retina allowing us to measure the thickness of those layers. These measurements help us diagnose, retinal issues as well as optical nerve issues, and treat them accordingly to your individual results.

Glaucoma Screening & Glaucoma, strokes, ocular tumors and brain tumors impact vision!

The Visual Field is a diagnostic tool used to detect defects in your field of view. These smart machines test your vision using lights in different angles and locations to test your periphery and central vision. It allows us to measure your field of view and lets us detect signs of Glaucoma, strokes, ocular tumors and brain tumors that may be affecting your eyes. It is so accurate even the DMV might ask you to have one done if you have difficulty passing your vision test there.

Stem Cell Therapy For Eyes

Many doctors doing research state that patients do see relief antibody when receiving stem cell injections (not FDA approved) from a joint shot or IV. More to come as science, technology and researchers are breaking new boundaries all the time. Eyy Drops and IN Stem Cells are not FDA approved, you may be able to find a research program paid or free, or the same under an IND or IRB along with a product that has an FDA Master File from the FDA.

Eye Drop Science

The unique combination of 3% trehalose and 0.15% HA found in iVIZIA has been extensively studied and demonstrated effective in multiple independent clinical studies.

Trehalose and HA increased tear film thickness (TFT) for up to 240 minutes after a single administration compared to HA alone (N=60, P<0.0001)⁹
Improved the thickness of the tear film for at least 4 hours (6× longer than HA alone)⁹

Trehalose/HA combination efficacy demonstrated in multiple studies:

Decreased ocular surface inflammation, shown by a significant reduction of tear cytokines after 2 months compared to baseline with 1 drop TID (N=15, P<0.05)¹⁰
Provided a majority of patients with greater improvement in Ocular Surface Disease Index (OSDI) score compared with HA alone at day 84, the end of study (62% had an OSDI score of none at day 84 compared with 40%, respectively; P=0.044, N=105)³
Patients reported symptom relief with significant improvements in blurred vision, stinging, and itching (P<0.05, N=105)³

Laser Vision Correction

There are many laser vision correction procedures. LASIK is a procedure where flap is created with a laser on the outer layers of the cornea and then the flap is gently folded back. An Excimer Laser is used to reshape the cornea. The flap is then put back in place, acting like a natural bandage. The “Wow!” effect of Lasik is the very rapid recovery of vision and minimal discomfort post-operatively. You hear from patients that they did not feel anything, and could see well the very first day. Most people have functional vision in 24 hours, although this is true in most cases, it must be noted that each person will heal at a different rate. Vision, although greatly improved immediately after surgery, continues to improve for some weeks, even months.

Everyone’s eyes are different. Even though you may have had a friend who has had LASIK, it does not mean it is right for you. If you are interested in laser vision correction, we will be happy to guide you in picking the right procedure for you.

Ocular Tram or Ocular Surface Tear

Embedded Foreign Bodies

A common injury is a metallic foreign body embedded in the cornea. Grinding or drilling in iron or other metals will release particles that are hot, and when they hit the eye, they embed themselves in the cornea. If it is iron, as in this example, it can cause a rust ring due to the salty consistency of our tears. At Village Vision, we would remove the metal piece and the remaining rust deposit that has infiltrated the surrounding cornea. The patient would then receive drops to help heal the cornea. With proper medical treatment these injuries will resolve well. Most injuries to the cornea can also be prevented with proper safety eyewear. The cornea (the clear window on the front of the eye) has more nerve pain sensors than any other part of the body. Injury to the cornea can be incredibly painful.

Retinal Trauma

Contusions, otherwise referred to as a “black eye,” can cause breaks or detachments in the back of the eye. The retina is the nerve tissue that senses light which lines the back of the eye. There is a blood vessel layer under the retina. This is very delicate and sensitive tissue. With retinal traumas, retinal tears or retinal detachments are possible the faster we are able to see you the more likely we are to prevent any vision loss. Call immediately when an injury occurs. We are here to help.

Flashes/Floaters

If you have symptoms of “Flashes of Light” in your vision, this could mean that there is something happening in the back of the eye. Flashes and floater could be normal aging changes, or can be evidence of a more serious eye condition. Call immediately for an appointment if you have any sudden flashes or floaters. We are here to help of reach out to

Stem Cells for Eyes

There are many providers and researchers using stem cells, Wharton jelly and exosomes in research at a different levels, but are not approved fully by the FDA. Many may qualify for research under a Master File product. If you are in need and have an ocular tear, or inflammation there are Amniotic Patchs that can be placed on the eye that are paid for by medicare that are in the same grouping but lifeolized similar to a product used in wound care. Stem Cells for Eyes may also come in drops, gels and patchs in the future.

Dry Eye Drop Citations & References

References: 1. Chen W, Zhang X, Liu M, et al. Trehalose protects against ocular surface disorders in experimental murine dry eye through suppression of apoptosis. Exp Eye Res. 2009;89(3):311-318. 2. Aragona P, Colosi P, Rania L, et al. Protective effects of trehalose on the corneal epithelial cells. ScientificWorldJournal. 2014;2014:717835. 3. Chiambaretta F, Doan S, Labetoulle M, et al. A randomized, controlled study of the efficacy and safety of a new eyedrop formulation for moderate to severe dry eye syndrome. Eur J Ophthalmol. 2017;27(1):1-9. 4. Liu Z, Chen D, Chen X, et al. Trehalose induces autophagy against inflammation by activating TFEB signaling pathway in human corneal epithelial cells exposed to hyperosmotic stress. Invest Ophthalmol Vis Sci. 2020;61(10):26. 5. US FDA Department of Health and Human Services. Ophthalmic drug products for over-the-counter human use. Updated October 21, 2021. Accessed January 19, 2022. https://www.accessdata.fda. gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=349. 6. Jones L, Downie LE, Korb D, et al. TFOS DEWS II management and therapy report. Ocul Surf. 2017;15(3):575-628. 7. Pisárčik M, Bakoš D, Čeppan M. Non-Newtonian properties of hyaluronic acid aqueous solution. Colloids Surf A Physicochem Eng Asp. 1995;97(3):197-202. 8. Rah MJ. A review of hyaluronan and its ophthalmic applications. Optometry. 2011;82(1):38-43. 9. Schmidl D, Schmetterer L, Witkowska KJ, et al. Tear film thickness after treatment with artificial tears in patients with moderate dry eye disease. Cornea. 2015;34(4):421-6. 10. Fariselli C, Giannaccare G, Fresina M, Versura P. Trehalose/hyaluronate eyedrop effects on ocular surface inflammatory markers and mucin expression in dry eye patients. Clin Ophthalmol. 2018;12:1293-1300. 11. Gabisson P, Briat B, Le Foll J, et al. Handiness and acceptability of the new ABAK bottle in chronically treated patients. A cross-sectional, retrospective and multicentre study. Ann Pharm Fr. 2010;69(1):22-29. 12. Hovakimyan M, Ramoth T, Löbler M, et al. Evaluation of protective effects of trehalose on desiccation of epithelial cells in three dimensional reconstructed human corneal epithelium. Curr Eye Res. 2012;37(11):982-989. 13. Luyckx J, Baudouin C. Trehalose: an intriguing disaccharide with potential for medical application in ophthalmology. Clin Ophthalmol. 2011;5:577-581. 14. Baudouin C, Messmer EM, Aragona P, et al. Revisiting the vicious circle of dry eye disease: a focus on the pathophysiology of meibomian gland dysfunction. Br J Ophthalmol. 2016;100(3):300-306. 15. Mochizuki H, Yamada M, Hato S, Nishida T. Fluorophotometric measurement of the precorneal residence time of topically applied hyaluronic acid. Br J Ophthalmol. 2008;92(1):108-111. 16. Li J, Roubeix C, Wang Y, et al. Therapeutic efficacy of trehalose eye drops for treatment of murine dry eye induced by an intelligently controlled environmental system. Mol Vis. 2012;18:317-329. 17. Čejková J, Ardan T, Čejka Č, Luyckx J. Favorable effects of trehalose on the development of UVB-mediated antioxidant/pro-oxidant imbalance in the corneal epithelium, proinflammatory cytokine and matrix metalloproteinase induction, and heat shock protein 70 expression. Graefes Arch Clin Exp Ophthalmol. 2011;249(8):1185-1194. 18. You IC, Li Y, Jin R, Ahn M, Choi W, Yoon KC. Comparison of 0.1%, 0.18%, and 0.3% Hyaluronic Acid Eye Drops in the Treatment of Experimental Dry Eye. J Ocul Pharmacol Ther. 2018;34(8):557-564. 19. Kojima T, Nagata T, Kudo H, et al. The Effects of High Molecular Weight Hyaluronic Acid Eye Drop Application in Environmental Dry Eye Stress Model Mice. Int J Mol Sci. 2020;21(10):3516. Published 2020 May 15. 20. Ehrenberg M, Zolotariov E, Loeb E, Poliansky V, Levy A. Combining Sodium Hyaluronate and Polyvinylpyrrolidone Therapies for the Rabbit Cornea: A New Approach to Relief of the Human Dry Eye Syndrome. Curr Eye Res. 2015;40(9):913-922. 21. Otto S, Roth HW. Wirksamkeit und Verträglichkeit eines Polyvidon-Präparates bei Behandlung von Benetzungsstörungen [Effectiveness and tolerance of a polyvidon substance in treatment of dry eye syndromes]. Klin Monbl Augenheilkd. 1996;209(6):362-367. 22. Baudouin C, Labbé A, Liang H, Pauly A, Brignole-Baudouin F. Preservatives in eyedrops: the good, the bad and the ugly. Prog Retin Eye Res. 2010;29(4):312-334. 23. Guillon M, Maissa C, Wong S. Symptomatic relief associated with eyelid hygiene in anterior blepharitis and MGD. Eye Contact Lens. 2012;38(5):306-312. 24. Serge Doan. Clinical Ophthalmology. January 10, 2012. Bichat Hospital and Foundation. Paris, France. 25. Data on File. Laboratoires Théa.